WebJun 9, 2015 · The intermediacy of an o-QM, formed upon the action of the acidic chiral phosphoric acid 7–10, was demonstrated by the following control experiments: (i) a free phenol moiety was found to be mandatory for the reaction to proceed enantioselectively; (ii) the substitution at the alcohol was not stereospecific (i.e., racemic or enantiopure ... WebJan 17, 2003 · As part of a study into the asymmetric synthesis of sialyltransferase inhibitors, we required a series of chiral, non-racemic meta-substituted α-hydroxybenzylphosphonates and initially prepared the diethyl phosphonates (S)-4a–c (Scheme 1) and (R)-4a–c in high ee, employing the procedure of Pogatchnik and Wiemer. 20 It was apparent, however, …

Chiral phosphoric acid-catalyzed stereodivergent synthesis of ... - Nature

WebJan 17, 2003 · As part of a study into the asymmetric synthesis of sialyltransferase inhibitors, we required a series of chiral, non-racemic meta-substituted α … WebApr 12, 2024 · We have developed a chiral phosphoric acid-catalyzed enantioselective Friedel–Crafts alkylation reaction between pyrroles and indolylmethanols. Wide substrate scope was observed, and a chiral all-carbon quaternary center was constructed at the 3 position of indoles in high yields with high to excellent enantioselectivities (up to 99% ee). east bay cable providers

Asymmetric Synthesis of Chiral Amino Carboxylic‐Phosphonic Acid ...

WebJan 17, 2003 · DOI: 10.1016/S0957-4166(02)00786-3 Corpus ID: 98088410; Chiral, non-racemic α-hydroxyphosphonates and phosphonic acids via stereoselective … WebNov 14, 2013 · Fosfazinomycins A and B produced by Streptomyces lavendofoliae share the same phosphonate moiety with one chiral centre of unknown configuration which was determined by synthesising both enantiomers of 2-hydroxy-2-phosphonoacetic acid methyl ester. A chiral cyclic phosphite was reacted with methyl glyoxylate in a Pudovik reaction … WebJan 22, 2024 · Chiral phosphoric acids (CPAs) have emerged as powerful organocatalysts for asymmetric reactions, and applications of computational quantum chemistry have … cuba monthly weather