Cisplatin atherosclerosis

WebStatins were associated with slower progression of overall coronary atherosclerosis volume, with increased plaque calcification and reduction of high-risk plaque … WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes …

Severe intestinal ischemia during chemotherapy for small cell …

WebAug 13, 2024 · Cisplatin was dissolved in dimethylformamide, and other chemicals were dissolved in dimethyl sulfoxide (DMSO) upon receipt. All chemicals were aliquoted and stored at −80 °C. Cell culture The... Web2 days ago · Radiation therapy (RT) significantly increased the incidence of coronary artery diseases, especially atherosclerosis. Endothelial dysfunction has been the major side effect of RT among tumor patients who received RT. However, the involvement between endothelial dysfunction and radiation-induced atherosclerosis (RIA) remains unclear. grace community church arroyo grande https://bowden-hill.com

Cisplatin related cardiotoxicity – acute and chronic …

WebMar 24, 2024 · Having an atherosclerosis-related disease may cause fear, anxiety, depression, and stress. You may worry about having heart problems or making lifestyle changes that are necessary for your health. Talk with your healthcare team about how you feel and actions you can take. Talk to a counselor. WebAug 14, 2024 · Lipopolysaccharide (LPS) is an endotoxin that induces systemic inflammatory responses. Melittin, a main constituent of bee venom, exerts several biological activities such as antioxidant, anti-inflammatory, and antiapoptotic actions. However, whether melittin protects against endotoxin-induced AKI remains undetermined. WebDec 30, 2024 · However, cardiovascular toxicity is a major concern. In addition to acute endothelial toxicity and associated risk of arterial thrombosis, accelerated atherosclerosis may be the result of chemotherapy-associated latent cardio-metabolic dysfunction. A 45-year-old man began treatment with cisplatin-based chemotherapy for testicular cancer. grace community church ann arbor

Hederagenin potentiated cisplatin- and paclitaxel-mediated

Category:Cardiovascular Complications of Cancer Therapy Circulation

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Cisplatin atherosclerosis

Gasdermin E deficiency attenuates acute kidney injury by …

WebApr 14, 2024 · Histone acetylation plays a vital role in organizing chromatin, regulating gene expression and controlling the cell cycle. The first histone acetyltransferase to be identified was histone acetyltransferase 1 (HAT1), but it remains one of the least understood acetyltransferases. HAT1 catalyzes the acetylation of newly synthesized H4 and, to a … WebRecently, a genome-wide analysis of cisplatin-induced peripheral neuropathy in survivors of adult-onset cancer reported that genetically determined expression level of RPRD1B …

Cisplatin atherosclerosis

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WebDec 16, 2024 · Introduction: Cisplatin-based chemotherapeutic regimen (CBCR) is known for increasing risk of venous thromboembolic (TE) disease. We report a unique case of STEMI associated with CBCR which we believe was caused by coronary artery … WebModern hypotheses introduce atherosclerosis as an inflammatory/lipid-based disease and NLRP3 inflammasome has been considered as a link between lipid metabolism and inflammation because crystalline cholesterol and oxidized low-density lipoprotein (oxLDL) (two abundant components in atherosclerotic plaques) activate NLRP3 inflammasome.

WebNational Center for Biotechnology Information WebNov 5, 2024 · Since its introduction in the late 1970s, cisplatin-based chemotherapy (CBCT) has revolutionized the treatment of metastatic testicular cancer (TC) and …

WebCisplatin causes direct and acute endothelial toxicity with a propensity to arterial thrombosis, irrespective of the presence of underlying atherosclerosis.7 Any longer …

WebAtherosclerosis is characterized by vascular obstruction from the deposits of plaque, resulting in reduced blood flow. Plaque rupture and the consequent thrombosis may lead to sudden blockage of the arteries and cause heart attack.

WebIn addition, BANCR induced the proliferation of vascular smooth muscle cells by downregulating miR-34c methylation in atherosclerosis. 34 Here, we could not exclude the possibility that BANCR may attenuate the killing capacity of cisplatin on GC cells by regulating miRNAs. Further investigation is needed in our future study. chill cool wallpaperWebFeb 1, 2024 · Cis-diamminedichloroplatinum (cisplatin) is an effective agent for treating solid tumors. However, its clinical use is limited by its serious toxic side effects; … chill cookie dough in freezerWebJul 1, 2016 · Nephrotoxicity is a well documented adverse effect of cisplatin use, with a dose-dependent and irreversible reduction in renal function. 75, 76, 77 Possible mechanisms include endothelial and epithelial cell damage and dysfunction. 78 Patients treated with cisplatin-based chemotherapy have a high prevalence of microalbuminuria … grace community church appWebJan 11, 2024 · High risk for progression includes those with a large plaque burden, a thin-cap fibroatheroma, low-attenuation, and positive vessel remodeling. Among patients with … chillcootsWebOct 10, 2024 · Late adverse vascular effects of platinum drugs have been attributed to platinum-related disruptions of vascular endothelial cells resulting in a … grace community church beckley wvWebJul 29, 2024 · The cancer-therapeutic drug, cisplatin, induces the release of GDF15 and activates GFRAL AP/NTS neurons, as well as causing significant reductions in food intake and body weight in mice. These … chill cooler systemWebAcute clinical syndromes associated with cisplatin infusion include chest pain, palpitations, and, occasionally, elevated cardiac enzymes indicative of myocardial … grace community church austin texas