Cisplatin hearing loss thesis

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August undefined, 2024

WebCisplatin may cause serious hearing problems, especially in children. Hearing loss may be permanent in some cases. Your doctor will order tests to monitor your hearing before and during your treatment. Tell your doctor and pharmacist if you have ever had radiation therapy to your head. Tell your doctor and pharmacist if you are taking ... WebHigh-dose cisplatin treatment: hearing loss and plasma concentrations. Fifty-four patients with metastatic cancer were followed audiometrically during high-dose (100-120 mg/m2) …

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WebJul 3, 2024 · Cisplatin-induced hearing loss is associated not only with dosage, but also with the administration protocol. Whether used in single high dose or multiple low dose, … WebHearing loss induced by cisplatin or aminoglycosides is generally bilateral and begins at high frequencies, extend-ing to lower frequencies with prolonged treatment. … iowa high school state wrestling 2022 bracket

Cisplatin-induced ototoxicity: Updates on molecular …

WebThe incidence of ototoxicity induced by cisplatin ranges from 20% to 70%, and it usually manifests as a progressive, bilateral and irreversible hearing loss. Although the etiology … WebApr 1, 2011 · As has proven to be the case with noise-induced hearing loss and age-related hearing loss, oxidative stress has a key role in cisplatin ototoxicity. Additionally, like with noise and aging, apoptotic cell death has been identified as the primary mode of cell death in cochleae exposed to cisplatin. WebCisplatin can cause irreversible hearing loss initially detectable as impairment of high-frequency hearing with progression to lower frequencies. Many patients receiving cisplatin are too ill to tolerate lengthy audiometric testing. Therefore, a rapid and sensitive high-frequency monitoring strategy … iowa high school state trap shoot 2022

NAC to Prevent Cisplatin-induced Hearing Loss - Full Text View ...

Routine Tests for Hearing Loss in All Cisplatin-Treated Patients

WebMay 19, 2024 · Cisplatin may cause hearing loss as a side effect. In the average-risk medulloblastoma patients, this trial tests whether the addition of sodium thiosulfate (STS) to standard of care chemotherapy and radiation therapy reduces hearing loss. Previous studies with STS have shown that it may help reduce or prevent hearing loss caused by … WebCisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of this … iowa high school state wrestlingWebImproved survival from childhood cancer has been achieved at the cost of long-term comorbidities that reduce quality of life. The chemotherapy agent cisplatin is essential for treatment of many paediatric and adolescent malignancies but in a large proportion of patients results in cisplatin-induced hearing loss, a debilitating and permanent late … iowa high school state wrestling 2023 live

"WebJan 25, 2024 · More than half of patients treated with cisplatin-based chemotherapy develop hearing loss or tinnitus, which can be devastating, say researchers who urge that all patients should be tested routinely. " - Cisplatin hearing loss thesis

Cisplatin hearing loss thesis

Cisplatin Ototoxicity in Children IntechOpen

WebOct 27, 2024 · In the pediatric population, cisplatin-induced hearing loss within the speech range can have a profound impact on cognitive development, leading to life-long complications 6,7,8. WebJan 1, 2024 · Atorvastatin use significantly reduces the odds of a clinically meaningful cisplatin-induced hearing loss. An analysis of the incidence of a CTCAE-defined hearing loss due to cisplatin therapy in the full cohort and key subgroups is shown. For the full cohort and the subject subgroups, the difference in the incidence (% of ears) and 95% CI …

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WebNov 29, 2024 · Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): A multicentre, randomised, controlled, open-label, phase 3 ... WebNoise-induced hearing loss (NIHL) is a complex disease which might be caused by interactions between environmental and genetic factors. Noise is the best-known and one of the most studied environmental factors causing hearing loss.

WebSynthese und Charakterisierung von neuen Dicobalthexacarbonyl-Komplexen als Cycl... 9 Referenzen [1] Titelblatt WebCISPLATIN-INDUCED HEARING LOSS IN CHOP KO MICE 2 Abstract Cisplatin is a chemotherapeutic drug that causes hearing loss, and the mechanisms of its ototoxicity …

Webhearing loss observed is typically irreversible, progressive, bilateral, high-frequency sensorineural hearing loss associated with tinnitus. At present there is no approved … WebJan 1, 2024 · Cisplatin-induced hearing loss is permanent, and there are currently no FDA-approved therapies to reduce or prevent cisplatin ototoxicity. Here we explore the …

WebJan 26, 2024 · A New Approach to Researching Cisplatin-Induced Hearing Loss. The new study differs from previous research because it is a comprehensive look at the pharmacokinetics, or concentration, of the …

WebBackground: Sensorineural hearing loss is a well-known side effect of cisplatin (CDDP). There is limited research on the effect of dosing, infusion times, and schedules of cisplatin administration and their impact on hearing loss. Methods: A retrospective review of 993 pediatric patients’ medical and audiological open arms free methodist churchWebJun 3, 2024 · The topic of my MSc thesis work was “Synthesis and Characterization of CuO-PVA Nanofluid for Heat Transfer Applications”. ... Cisplatin-induced ototoxicity (CIO), manifests as permanent, bilateral, high frequency sensorineural hearing loss that is estimated to affect 26-90% of children that has debilitating effects on children’s ... iowa high school state wrestling 2023 resultsWeb• Investigating molecular mechanisms underlying cisplatin and noise-induced hearing loss • Determining the role of transplatin as an … open arms guitar tabWebThis thesis is based on the following original papers, which will be referred to in the text by their Roman numerals I-V. Ekborn A, Laurell G, Andersson A, Wallin I, Eksborg S, Ehrsson H. Cisplatin-induced hearing loss: influence of the mode of drug administration in the guinea pig. Hear Res 2000;140(1-2):38-44. open arms free clinic elkhorn wi open arms haverstrawWebSep 24, 2024 · As cisplatin is an effective treatment for cancer, researchers have focused on finding ways to counteract the associated hearing loss. Combination therapies, where a protective compound (otoprotectant) such as antioxidants, anti-inflammatories, and steroids are administered alongside cisplatin, aim at decreasing the probability of the patient ... iowa high school state volleyball 2022WebNov 21, 2024 · Cisplatin chemotherapy causes permanent hearing loss in 40-80% of treated patients. It is unclear whether the cochlea has unique sensitivity to cisplatin or is exposed to higher levels of the drug. Here we use inductively coupled plasma mass spectrometry (ICP-MS) to examine cisplatin pharmacokinetic … open arms guitar chords